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Objective@#To evaluate the clinical outcome and health related quality of life in degenerative patients with kyphoscoliosis who underwent S2AI placement and identify the potential risk factors of pelvic incidence variation postoperative and at last follow-up.@*Methods@#The present study reviewed degenerative patients with kyphoscoliosis who accepted surgery utilized S2AI screw between January 2015 and January 2019. 25 patients were included in our study, 4 males and 21 females, among these patients, the mean age were 58.84±6.03 years, range from 50-68 years. All patients were conducted long fusion distal to pelvis utilizing S2AI screws. According to the variation of pelvic incidence at last follow-up, we divided patients into two subgroups: 1) Group I: Patients' pelvic incidence increased more than 5 degree compared with post-operation. 2) Group S: Patients' pelvic incidence varied less than 5 degree compared with post-operation. 13 patient (2 male, 11 female; mean age: 57.23±6.06 years) were categorized into group I, and 12 patients (2 male, 10 female; mean age: 60.58±5.73 years) were categorized into group S.Cobb′s angle, lumbar lordosis(LL), regional kyphosis(RK), sagittal vertical axis(SVA), pelvic incidence(PI), pelvic tilt(PT), sacral slop(SS) were recorded at pre-operation, post-operation and last follow up. The MOS item short from the health survey(SF-36) and Oswestry disability index (ODI) were also recorded at pre-operation and last follow up.@*Results@#There was no statistical difference in gender, age, preoperative Cobb angle, SVA between two groups. In group I, pelvic incidence were decreased postoperatively and increased at the last follow-up (56.92°±14.47° vs 42.69°±14.23° vs 51.62°±14.53°, P<0.05). In group S, pelvic incidence were decreased postoperatively (46.21°±12.26° vs 37.08°±12.99°, P<0.05) and remained stable at the last follow up (37.08°±12.99° vs 37.17°±13.34°, P>0.05). Cobb angle (46.08°±20.52° vs 19.96°±12.64° vs 20.28°±12.01°), RK (32.88°±15.28° vs-12.16°±17.75° vs-11.64°±17.29°), SVA (94.61±92.59 mm vs 25.49±23.89 mm) were improved significantly after surgery and remained stable at the last follow-up. HRQoL score was improved significantly in all patients at the last follow-up compared with preoperative (SF-36 PCS: 36.88±10.89 vs 67.91±10.46, P<0.05; SF-36 MCS: 33.48±10.96 vs 60.19±8.10, P<0.05; ODI: 46.00%±13.54% vs 23.40%±8.86%, P<0.05).@*Conclusion@#Pelvic fixation utilizing S2AI screw can provide substantial correction and patients' HRQoL can be improved significantly after surgery. Meanwhile, PI changed at the last follow-up in partial patient. The variation of PI may be associated with the preoperative sagittal malalignment.
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Objective To evaluate the clinical outcome and health related quality of life in degenerative patients with ky?phoscoliosis who underwent S2AI placement and identify the potential risk factors of pelvic incidence variation postoperative and at last follow?up. Methods The present study reviewed degenerative patients with kyphoscoliosis who accepted surgery uti?lized S2AI screw between January 2015 and January 2019. 25 patients were included in our study, 4 males and 21 females, among these patients, the mean age were 58.84±6.03 years, range from 50-68 years. All patients were conducted long fusion distal to pelvis utilizing S2AI screws. According to the variation of pelvic incidence at last follow?up, we divided patients into two subgroups: 1) Group I: Patients' pelvic incidence increased more than 5 degree compared with post?operation. 2) Group S:Patients' pelvic incidence varied less than 5 degree compared with post?operation. 13 patient (2 male, 11 female; mean age:57.23±6.06 years) were categorized into group I, and 12 patients (2 male, 10 female; mean age: 60.58±5.73 years) were catego?rized into group S.Cobb′s angle,lumbar lordosis(LL),regional kyphosis(RK),sagittal vertical axis(SVA), pelvic incidence(PI), pelvic tilt(PT), sacral slop(SS) were recorded at pre?operation,post?operation and last follow up. The MOS item short from the health survey(SF?36) and Oswestry disability index (ODI) were also recorded at pre?operation and last follow up. Results There was no statistical difference in gender, age, preoperative Cobb angle, SVA between two groups. In group I, pelvic inci?dence were decreased postoperatively and increased at the last follow?up (56.92°±14.47° vs 42.69°±14.23° vs 51.62°±14.53°, P＜0.05). In group S, pelvic incidence were decreased postoperatively ( 46.21°± 12.26° vs 37.08°± 12.99°, P＜0.05) and re?mained stable at the last follow up ( 37.08°±12.99° vs 37.17°±13.34°, P＞0.05). Cobb angle (46.08°±20.52° vs 19.96°±12.64° vs 20.28°± 12.01°), RK (32.88°± 15.28° vs-12.16°± 17.75° vs-11.64°± 17.29°), SVA (94.61 ± 92.59 mm vs 25.49 ± 23.89 mm) were improved significantly after surgery and remained stable at the last follow?up. HRQoL score was improved significantly in all patients at the last follow?up compared with preoperative (SF?36 PCS: 36.88±10.89 vs 67.91±10.46,P＜0.05; SF?36 MCS:33.48±10.96 vs 60.19±8.10, P＜0.05; ODI: 46.00%±13.54% vs 23.40%±8.86%, P＜0.05). Conclusion Pelvic fixation utiliz?ing S2AI screw can provide substantial correction and patients'HRQoL can be improved significantly after surgery. Meanwhile, PI changed at the last follow?up in partial patient. The variation of PI may be associated with the preoperative sagittal malalignment.
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Objective To compare the clinical outcomes of neuromuscular scoliosis(NMS)patients with pelvic obliquity who underwent spino-pelvic fixation utilized traditional iliac screw(IS),second sacral alar-iliac(S2AI)screw or iliac sacral screw. Methods All of 20 patients who met the inclusion were included in this study,with 14 cases of poliomyelitis,4 cases of spinal muscular atrophy, 2 cases of muscular dystrophy,with 11 patients utilizing IS, 6 patients utilizing S2AI,and 3 patients utilizing ISS.The radiographic parameters measured pre-and post-operation and at last follow up included coronal Cobb angle,pelvic obliq-uity,and regional kyphosis.The SRS-22 questionnaires and the Oswestry disability index(ODI)and complications were collected. Results There were no significant difference in age,Cobb angle,pelvic obliquity and regional kyphosis among three groups,the follow up times was significantly shorter in the ISS group(H=15.183,P<0.01).In the IS group,the Cobb angle at pre-or post-oper-ation and at last follow up measured 70°,35°and 40°,the pelvic obliquity measured 24°,11°and 12°,the regional kyphosis mea-sured 36°,12°and 14°.In S2AI group,the Cobb angle measured 70.5°,25.0°and 26.5°,the pelvic obliquity measured 20°,10° and 11.5°,the regional kyphosis measured 37°,12°and 12.5°,showing significant improvement compared to pre-operation(P<0.05).In the ISS group,the Cobb angle at pre or post operation and at last follow up measured 64°,25°and 27°,the pelvic obliqui-ty measured 24°,9°and 11°,the regional kyphosis measured 53°,8°and 8°,showing a decrease after surgery with P>0.05,which may attribute to the small sample size in ISS group.The pre-operative ODI score was 42%,45% in IS and S2AI group,improving significantly to 26%,25.5% at last follow up.The ODI score in ISS group improved from 36% to 24% after surgery(P=0.068).The SRS-22 score improved significantly in three groups,with P<0.05 in IS and S2AI group and P=0.066 in ISS group.In the IS group, one patient had rod breakage and underwent revision surgery,one patient had deep infection and recovered with conservative treat-ment.In the S2AI group,one patient had S2AI screw misplacement on the right side.Conclusion In the surgical management of neuromuscular scoliosis(NMS)patients with pelvic obliquity,the utilization of either iliac screw,S2AI screw or ISS fixation can ob-tain satisfied deformity correction and improvement in health-related quality of life,however,the utilization of S2AI and ISS could reduce the implant related complications.
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Objective To establish a kind of mesenchymal stem cells(MSCs) model that could express hCD4 and hCCR5 to study the field of human immunodeficiency virus type 1 (HIV-1).Methods Lentiviral vectors containing the genes of hCD4 and hCCR5 under the transcriptional control of cytomegalovirus promoter were designed.MSCs were transfected by the lentiviral vectors at optimum multiplicity of infection.Transduction efficiencies of hCD4 and hCCR5 in MSCs were analyzed by quantitative real-time polymerase chain reaction(RT-PCR),Western blot,and immunofluorescence staining.Subsequently,the transfected human MSCs were infected with HIV-1,and the expression of HIVRNA in the MSCs was detected by RT-PCR.Results The MSCs model con-taining hCD4 and hCCR5 and supporting normal HIV-1 infection was constructed.qRT-PCR showed that MSCs upon infection with lentiviral vectors were highly expressed in hCD4 and CCR5 mRNA sequences(P＜0.01).Western blot detection showed the positive bands of 55.0 × 103 (hCD4) and 40.6 × 103 (hCCR5).The results of immunofluorescence staining revealed that hCD4 and CCR5 were expressed on the surface of MSCs.Such results were not found in cells infected with empty lentiviral vectors.And the susceptibility of the hCD4/CCR5 transgenic MSCs to the HIV-1 was further indicated by the detection of HIV-1 RNA in the culture supernatants and cell lysates(P＜0.05).Conclusion The MSCs model that could highly express hCD4 and hCCR5 was established to support normal HIV-1 infection,which can be used to investigate the development of new therapies and vaccines against HIV.
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In this study, the optical data of tongue color of different syndromes in primary hepatic carcinoma (PHC) were detected by optical spectrum colorimetry, and the chromaticity of tongue color was compared and analyzed. The tongue color characteristics of different syndromes in PHC and the relationship between different syndromes and tongue color were also investigated.
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Using the data from normal tongue and lip colors of normal people which were collected by the visible reflection spectrum, we analyzed the colorimetric parameters of tongue and lip colors.
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In this study, optical data on color of tongue tips were collected by using a visible reflection spectrum system. Quantitative method of tongue inspection and classification of tongue states including pale, pale red, red and crimson manifestations were investigated.
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In this study, to analyze the influence of the brightness value of the supranasal point and the apex nasi on their dominant wavelength and excitation purity according to the spectrocolorimetry data of the supranasal point and the apex nasi in healthy adults that were collected based on optical spectrum colorimetry.
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As an important medical instrument in percutaneous transluminal coronary angioplasty, endovascular stents must have excellent biocompatibility. In this paper, after a description of the performance and fabrication process of stents, we analyzed the technology to improve the biocompatibility of stents during the fabrication process which is the effective method for decreasing the rate of restenosis.
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Animals , Humans , Angioplasty, Balloon, Coronary , Coronary Disease , Therapeutics , Coronary Restenosis , StentsABSTRACT
Objective To observe the effect of Yiqi Huayu Recipe on the expression of protein kinase C (PKC) and CyclinE in rats with gastric precancerous lesions (GPL). Methods The model of GPL was established mainly through N-methyl-N-nitro N-nitrosoguanidine (MNNG) together with other factors including alcohol stimulation and undue hunger and overeating. The survived rats after modeling were randomly divided into spontaneous recovery, and high-, moderate- and low-dose Yiqi Huayu group. After the corresponding treatment, the expression of PKC and CyclinE were detected by immunohistochemical method in each group. Results The expression of PKC and CyclinE in trement group were distinctly lower than those in spontaneous recovery group (P
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OBJECTIVE: Amyotrophic lateral sclerosis(ALS) is a chronic progressive degenerative disease selectively infringing upper and lower motoneurons, and its pathogeny and pathogenesis are unclear till now. Its researches are mainly relying on animal models. Currently, there are many methods for the establishment of ALS animal.model and each of them has its own characters,practicability and values.DATA SOURCES: Relative articles during the period from January 1980 to December 2003 were searched on the Medline database by the title of the article with the searching word "amyotrophic lateral sclerosis, model" and the language of the articles was limited to English.STUDY SELECTION: Data were preliminarily screened for the selection of the literatures mainly regarding the researches of ALS animal models; and then literatures regarding the application of ALS animal model in medication effectiveness and pathogenesis were eliminated; the full texts of the rest literatures were searched as inclusive criteria.DATA EXTRACTION: Totally 96articles searched with "amyotrophic lateral sclerosis, model" in title were collected. Fifteen tests were in accordance with the inclusive criteria. In the eliminated 81 tests, 75 literatures were about the researches on the application of ALS model for medication observation and pathogenesis research, and the rest 6 articles were repetitive experiments.DATA SYNTHESIS: ALS neurotoxic animal model, immune mediated animal model, spontaneous animal model, and transgenic animal model were established in the selected literatures, which also investigated the mechanism, features, practicability and value of the animal model.CONCLUSION: The establishment of animal models simulated ALS symptoms or pathogenesis in the above literatures can be used in ALS disease researches as referencing model, which could provide animal experimental basis for the researches of ALS pathogenesis and the confirmation of therapy plan.
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[Objective] To observe the anti - aging effects and explore the mechanism of Qibao Meiran Pellet (QMP) and its modified prescriptions, including QMP with qi - invigorating and spleen - strengthening herbs, with kidney -nourishing herbs or with blood - activating and purgative herbs. [ Methods ] Ten - month - old model rats were established by D - galactose. Serum free radical levels and immune indexes in QMP group and various modified QMP groups were observed. [ Results ] QMP increased the activity of superoxide dismutase ( SOD). QMP combined with kidney - nourishing herbs or blood - activating and purgative herbs decreased the serum level of malondialdehyde (MDA) and increased the activities of glutathione peroxidase (GSH - Px) and SOD. Meanwhile, QMP combined with kidney -nourishing herbs increased interleukin - 2 activities. [ ConclusionJ QMP, mainly composed of herbs for nourishing liver and spleen, can delay the aging of rats, and spleen - strengthening herbs and blood - activating and purgative herbs also play an important role in the delay of aging. Furthermore, it is suggested that the anti - aging effect of herbal medicine is related to the sex.
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Objective To observe the clinical effect of Chi nese herbs Biejia Ruangan pill(BRP)on fibrosis in chronic hepatic B.Methods Ninety -eight patients with liver fibrosis of chronic hepatitis B were ra ndomly divided into two groups of BRP ,treatment group and co ntrol group,in which clinical manif estation scoring,liver function an d serum marker of hepatic fibrosis were obse rved.Results BRP could obviously improve the clin ical manifestation scoring,liver function and serum marker of hepatic fibrosis as compared with the contro l group.Conclusion Chinese herbs BRP could treat liver fibrosis of chronic hepatitis B effectively.